Copeptin, a 39-amino acid glycopeptide, is the C-terminal part of the prohormone of arginine vasopressin (AVP) or antidiuretic hormone (ADH).
The pre-pro-vasopressin precursor is synthesized and processed into its three components – AVP, Neurophysin II and Copeptin – within the hypothalamus; afterwards these products are transported along the neuronal axons in the granules of the posterior hypophysis (pituitary gland), where they are stored and released under appropriate stimulus.
Copeptin – the stable surrogate marker of vasopressin
Copeptin is released together with AVP in equimolar amounts but while the measurement of the unstable AVP is prone to pre-analytical errors, Copeptin constitutes a stable surrogate marker for this key hormone in the human body.
The extraordinary stability of Copeptin eases lab logistics: The Thermo Scientific B·R·A·H·M·S Copeptin proAVP KRYPTOR assay reliably replaces the measurement of vasopressin and opens the possibility to achieve the full diagnostic potential of this hormone in rule-out of myocardial infarction (AMI) and water-balance disorders.