Pathophysiology of copeptin release - AVP and Copeptin Release in Hypothalamus and Pituitary and its Effects

Synthesis of pro-AVP,
the precursor hormone
of AVP and Copeptin,
in the neurons of the
paraventricular and
the supraoptic nucleus

Cleavage of AVP and
Copeptin and transport
down the axons

AVP and Copeptin
storage in axons in
the posterior pituitary

AVP and Copeptin release
into nearby capillaries upon
appropriate stimulation

Synthesis of Pro-AVP
in parvocellular neurons

AVP and Copeptin
release into capillaries
of the portal system

Portal vessels carry AVP
and Copeptin directly to
the anterior pituitary

AVP stimulates endocrine
cells to release ACTH

	AVP synthesized by paraventricular and supraoptic nucleus
	AVP synthesized by neurons releasing hormones into the anterior pituitary
	ACTH